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Our recent research has provided the first evidence from randomised trials that riboflavin, a key B-vitamin, modulates DNA methylation of hypertension-related genes in adults with the MTHFR 677TT genotype. MTHFR, through its role in one carbon metabolism, supplies methyl groups for DNA methylation which controls gene expression. Riboflavin is a co-factor for MTHFR, and this gene-nutrient interaction has previously been shown by collaborators in NICHE to play an important role in hypertension. Ongoing collaborative work with NICHE is providing novel insights into personalised hypertension management and treatment.