Dr William Duddy
Lecturer in Stratified Medicine (Bioinformatics)
- School of Biomedical Sciences
- Research Institute
- Biomedical Sciences Research Institute
School of Biomedical Sciences
C-TRIC Building, Altnagelvin Area Hospital
Glenshane Road, Derry~Londonderry
- +44 28 7167 5686
Bill graduated from the University of Glasgow in 2005 with a BSc Hons degree in Molecular & Cellular Biology, earning the class prize for his year, and a PhD in Biochemistry.
During his PhD he carried out computational analyses of protein and drug interaction geometry, learning various large data analytical techniques and programming. He then did wet-lab systems biology research at the Department of Integrative Systems Biology at Children’s National Medical Center, Washington DC, where he ran transcriptome, proteome, and secretome analyses on cell and mouse models of muscle disease, as well as studying muscle stem cell behaviour.
Before taking up his lectureship at the Northern Ireland Center for Stratified Medicine, Bill was project leader in bioinformatics at the Center of Research in Myology (Sorbonne Universities, Paris), where he developed and applied data mining and systems biology approaches to muscle disease, focused on the functional analyses of omics data.
His most recent tool was CellWhere, for the graphical display of gene association networks organised on subcellular localizations. He was also involved in the in silico design of exon skipping oligonucleotides for genetic diseases such as Duchenne muscular dystrophy (DMD), and of novel truncated dystrophin proteins for DMD gene therapy.
In neuromuscular disorders he is motivated by his personal background, having had a brother with DMD.
In stratified medicine, Bill is interested to use network biology to identify clusters of interacting genes or proteins that influence the severity of a disease or that can affect a patient’s response to a given therapy.
His major focus is the pathology of neuromuscular diseases, on which he has developed several bioinformatics tools for the functional analysis of omics data. This includes Amyotrophic Lateral Sclerosis, where he works closely with Stéphanie Duguez to explore the role of muscle in this disease.
Bill is creator of the SysMyo network.
Showing 1 to 10 of 23 publications
To view all publications please visit Ulster University Institutional Repository (UIR)
- Quantitative antisense screening and optimization for exon 51 skipping in Duchenne muscular dystrophyMolecular TherapyDate: (2017)
- Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscleHuman Molecular GeneticsDate: (2017)
- Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell linesSkeletal MuscleDate: (2016)
- Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle.Cell reportsDate: (2015)
- Altered secretion of exosomes by muscle cells: role in ALS pathogenesisAltered secretion of exosomes by muscle cells: role in ALS pathogenesisDate: (2015)
- CellWhere: graphical display of interaction networks organized on subcellular localizations.Nucleic acids researchDate: (2015)
- Age-associated methylation suppresses SPRY1, leading to a failure of re-quiescence and loss of the reserve stem cell pool in elderly muscleCell reportsDate: (2015)
- In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in Duchenne muscular dystrophyPloS oneDate: (2015)
- Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasiaSkeletal muscleDate: (2015)
- Changes in communication between muscle stem cells and their environment with agingJournal of Neuromuscular DiseasesDate: (2015)