Overview
Dr Moffett’s present research is funded by a prestigious 5-year RD Lawrence Fellowship awarded by Diabetes UK which explores how infertility develops in women with obesity-diabetes.
In particular, she is investigating whether using drugs to balance the levels of different gut hormones could help these women to have children in the future.
This research builds on a strong portfolio of recent and ongoing research looking at the role of non-classical islet peptides in beta-cell function and the intra-islet adaptive responses to pregnancy, increased insulin demand and type 2 diabetes.
Such research has explored the relevance of local alpha-cell production of GLP-1 and the modulatory effects of established and new antidiabetic drugs on the process of islet cell transdifferentiation necessary for building beta-cell mass.