Dr Stephanie Duguez
Lecturer in Stratified Medicine (Musculoskeletal Health)
- School of Biomedical Sciences
- Research Institute
- Biomedical Sciences Research Institute
School of Biomedical Sciences
C-TRIC Building, Altnagelvin Area Hospital
Glenshane Road, Derry~Londonderry
- +44 28 7167 5687
Dr Duguez undertook her primary degree in Biological Sciences at Jean Monnet University (Saint Etienne, France) graduating in 1998, followed in 1999 by a MRes in “Adaptations and survival in extreme environments” at Claude Bernard University Lyon (Lyon, France).
Her PhD in “Human Motricity and Handicap” was undertaken at Jean Monnet University (Saint Etienne, France) (2003), during which time she was an Associate Lecturer at Jean Monet University (Saint Etienne, France).
She was then appointed as a post-doctoral Research Fellow working on Limb Girdle Muscular Dystrophy type 2A, at Genethon (Evry, France) from 2004-2006, and from 2007 to 2011 Dr Duguez was a Research Associate on Duchenne Muscular Dystrophy at Children’s National Medical Center (Washington, US). She was Project leader at the Institute of Myology, affiliated to Sorbonne University, UPMC Paris6, INSERM U974 (Paris, France) from 2012-2016.
Stephanie was appointed to her current post as Lecturer in Stratified Medicine in 2016, she is also a regular reviewer for a number of cell biology journals (Publons).
Dr. Duguez’s research is focused on exploring the intercellular communication between muscle and their surrounding cells including motor neurons, inflammatory cells or fibroblasts.
For this purpose, she is using human muscle stem cells and studying their secretome profiles using different OMICS approaches such as proteomic, metabolomic, transcriptomic analysis.
She aims to decipher the role of this intercellular communication in different physiological and pathological conditions such as Amyotrophy Lateral Sclerosis (ALS), Spinal and Bulbar Muscular Atrophy (SBMA), Spinal Muscular Atrophy (SMA-III & IV). Characterizing the muscle secretome will allow her to identify biomarkers and to unravel new therapeutic strategies for this adult motor neuron disorders.
Her research has been supported by several associations such as DPP-NL, AFM, ARsLA.
BIO122 Anatomy and Physiology
BIO338 Neurological Disease for stratified medicine
BIO340 Psychiatry for stratified medicine
BIO536 Clinical trials design & patient recruitment (Module Coordinator)
Bio542 Stratified Medicine & Healthcare Innovation (Module Coordinator)
BIO832 Stratified Medicine & Healthcare Innovation
Module co-ordinator for:
BIO536 Clinical trials design & patient recruitment (BSc (Hons) Stratified Medicine)
BIO542 Stratified Medicine & Healthcare Innovation (BSc (Hons) Stratified Medicine).
More information on Dr Duguez can be found on these platforms:
Showing 1 to 10 of 34 publications
To view all publications please visit Ulster University Institutional Repository (UIR)
- Correction of the exon 2 duplication in DMD myoblasts by a single CRISPR/Cas9 system.Correction of the Exon 2 Duplication in DMD Myoblasts by a Single CRISPR/Cas9 SystemDate: (2017)
- Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell linesSkeletal MuscleDate: (2016)
- Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle.Cell reportsDate: (2015)
- Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophyAnnals of neurologyDate: (2015)
- Altered secretion of exosomes by muscle cells: role in ALS pathogenesisAltered secretion of exosomes by muscle cells: role in ALS pathogenesisDate: (2015)
- CellWhere: graphical display of interaction networks organized on subcellular localizations.Nucleic acids researchDate: (2015)
- Age-associated methylation suppresses SPRY1, leading to a failure of re-quiescence and loss of the reserve stem cell pool in elderly muscleCell reportsDate: (2015)
- CellWhere: graphical display of interaction networks organized on subcellular localizationsNucleic acids researchDate: (2015)
- Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasiaSkeletal muscleDate: (2015)
- Changes in communication between muscle stem cells and their environment with agingJournal of Neuromuscular DiseasesDate: (2015)