Self-funded PhD opportunity

Stratified Medicine


Overview

The Northern Ireland Centre for Stratified Medicine (NICSM) was established in Autumn 2013 to focus on better approaches for the treatment of a range of degenerative and metabolic diseases including heart disease, diabetes, cancers, mental health, arthritis and neuromuscular disease.

Stratified medicine (also known as personalised or precision medicine) is an approach, which subdivides patients into groups based on their risk of developing specific diseases or their response to particular therapies. Stratified medicine is recognised as a key global priority for healthcare providers, pharmaceutical and diagnostic industries and patients. The ultimate aim of a stratified approach to medicine is to enable healthcare professionals to provide the 'right treatment, for the right person, at the right time.'

Stratified Medicine relies on using biological markers to separate patients into specific groups for diagnosing and treating disease at much earlier time points than currently possible. In order to realise the potential benefits of stratified medicine, advances in technologies and systems are required to reliably predict disease, select the best treatment and reduce side effects for each individual patient.

At NICSM, we have the largest single critical mass of researchers solely focused on stratified medicine in Ireland.  We have 23 Core staff, 19 PhD students, and 36 NHS Clinicians affiliated to our Research Centre. Our researchers are molecular biologists, clinicians and bioinformaticians/data scientists and we are committed to multidisciplinary research across the fields of molecular biology and data science to help drive our research.

Our Centre is based in the Clinical Translational Research and Innovation Centre (C-TRIC) on the Altnagelvin Hospital site in Derry/Londonderry. Our facility comprises clinic rooms for the recruitment of research participants, cell culture facilities, molecular and microbiology labs and server access for data analysis.


Summary

Biomedical Science at Ulster University has an outstanding record of success in research, having been awarded the highest possible rating in RAE1996 and 2001, and ranked first place in terms of research power in RAE2008. In REF2014, we were judged to be among the top five universities in terms of research power (out of 92 UK submissions) with 100% four star rating for our research environment.

Biomedical Sciences research activities are currently organized within distinct Research Groups: Diabetes, Food & Health (through Nutrition Innovation Centre for Food and Health (NICHE)), Genomic Medicine, Pharmaceutical Sciences & Practice, Stratified Medicine and Vision Science.

Multi-disciplinary collaboration between the research groups is strongly encouraged and is widespread with research into, for instance, anti-diabetic and antioncogenic aspects of nutrition, the genomics of vitamin receptors, visual deterioration or cancer, imaging of neovascularisation. Our research investigates the interaction between cardiovascular disease and vision and the impact of health and disease, diet, diabetes on dementia, hypertension, vascular and inflammatory disease, to name a few.

In practice, the research groups collaborate both internally and internationally on a range of prioritized multi-disciplinary themes in: ageing, drug discovery and delivery, personalized medicine and genomic medicine. There is also opportunity to undertake research in a number of multi-disciplinary research areas, which combine cutting edge Biomedical Sciences research with psychology, computing and engineering and computational biology. The BMSRI has strong collaborations with regional and global pharmaceutical and diagnostics companies and many of our graduates and postgraduates gain employment in the pharma, diagnostics and health care sectors as well as academia.


About

The BMSRI offers a “state-of-the-art” research environment for high profile researchers to undertake internationally agenda setting research in strategically prioritized areas of biomedicine. This research environment earned Biomedical Sciences at Ulster a No. 1 ranking in RAE2008, and was again rated as 100% “world-leading” in REF2014. Our research is carried out in well-equipped laboratories allowing the latest methods to be applied to individual projects. Our entire infrastructure is managed as Core Facility Units (CFUs) with equipment and laboratories dedicated to: advanced molecular bioimaging/microscopy, bioinformatics, cell biology, chemical analysis, genomics, proteomics/metabolomics (include Mass Spectrometry & NMR analysis), transgenics, physiology and pharmacology.

The BMSRI research infrastructure also includes centralized resources for: high throughput drug screening in vitro assays, clinical research & human intervention studies/ trials; the use and storage of mammalian cells and tissues; and in vivo studies in Animal reporter gene models and animal models that replicate human disease. The BMSRI uses its estate of equipment, specialist laboratories, infrastructure and internationally recognized biomedical expertise to offer clinical & translational services to Academic Researchers and Industrial Business partners. The BMSRI routinely engages in collaborative research with some of the world’s leading pharmaceutical and biomedical companies and through the support of Ulster’s Office of Innovation, the University has established a track record of success in the commercialization of its research outcomes.

At C-TRIC, clinicians, academics and businesses in the life and health sector can collaborate to facilitate the research, development and launch of innovative health technologies, medical devices and therapeutics. In addition to high-spec capabilities such as human genome sequencing, FLOW cytometry and tissue culture, C-TRIC’s hospital location also permits direct access to NHS diagnostic laboratories and Clinical Research Nurses, and its on-site office of the Western Trust’s Research and Development department provides access to expertise in research governance and healthcare economics.


Entry requirements

Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study. We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction.

In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications.

Additional information for International applicants may be found here.


English language requirements

In order to be admitted to research study at Ulster, you will need to provide evidence of your English language proficiency as part of your application.

Full details on the requirements for both home and overseas applicants can be found here.


Careers and opportunities

PhD graduates are recognised by employers to hold valuable transferrable skills, as the nature of the degree trains candidates in creativity, critical inquiry, problem solving, negotiation skills, professionalism and confidence.

The most recent Ulster survey of PhD graduates found that 92% had secured employment within the first year since graduation (HESA Destination of Leavers Survey 2015), and while two thirds end up in the Higher Education or Research sectors, the range of skills acquired equips the remainder for employment in a wide range of contexts.


Fees and funding

Tuition fees:

Details of tuition fees can be found under the fees schedule for the academic year of entry.

To work out for which fees you would be eligible and to find out more information about potential sources of funding, please view the Fees and Funding pages on the Doctoral College website.


Apply

We are delighted that you are considering Ulster University for your research studies.  Full details on the application process and further guidance on how to apply, and what you will need to upload as part of your application, is available here.

Once you have identified supervisors, discussed a research proposal and are ready to make an application, please apply using the online application system.

Ulster University welcomes applications from all sections of the community and from persons with disabilities. It is University policy to assess all applications using academic criteria and on the basis of equality of opportunity and you should be assured that reasonable adjustments will be made should you require them.


Reviews

My experience has been great and the people that I have worked with have been amazing

Kieran O'Donnell - 3D printing of biological cells for tissue engineering applications

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Completing the MRes provided me with a lot of different skills, particularly in research methods and lab skills.

Michelle Clements Clements - MRes - Life and Health Sciences

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Throughout my PhD I’ve been provided with continuous support and guidance by my supervisors and the staff at the University.I’ve also received many opportunities to further enhance my professional development in the form of teaching experience and presenting my work at conferences which will aid in my pursuit of a career in academia or industry.

William Crowe