Funded PhD Opportunity

Computational approaches to investigate multimorbidity in depression

Subject: Biomedical Sciences


Summary

Background:

Depression is a complex heterogeneous disorder. In severe depressive episodes, patients experience feelings of hopelessness/worthlessness, and suicide is a prominent risk. As the leading cause of global disability1, 300 million people are affected by depression and public health figures indicate depression accounts for 76.4 million years lost to disability; more than any other condition2. NI has one of the highest rates of depression in Europe with a lifetime prevalence rate of 16.3%3 and continues to have the highest rate of suicide of any UK country, at 16.5/100,000 (NISRA, reported by BBC News). NI has a 20-25% higher prevalence rate of mental health problems than the rest of the UK, with associated costs of £3.5 billion. The cost of depression to the UK economy is £70-£100 billion/year. Depression is often co-morbid with chronic physical conditions, particularly those with an inflammatory aetiology including CVD, diabetes and rheumatoid arthritis. In fact, a recent analysis of primary care patients reported that individuals with depression were more likely to have any one of 32 physical health conditions examined than those with no history of depression4. The concurrent occurrence of multiple chronic diseases in a single patient is known as multimorbidity and it is the most common chronic condition affecting more than 50% of people over the age of 65. Inflammation has been reported as a common occurrence in many patients exhibiting co-morbid or multimorbid diseases. Patients with multimorbidity have complex treatment needs that are not met by the single index disease-oriented approach. Thus there is an unmet need for better diagnostics and tailored therapies for patients with multimorbidity. In this project, our focus will be to investigate multimorbidity, specifically in depression.

Dataset:

Northern Ireland Centre for Stratified Medicine (NICSM) has recently procured access to the UK Biobank dataset, including, genomic, biochemical, diagnosis, medication/treatment, demographic/local-environment data of 500,000 participants. Approximately 20,000 of these participants are diagnosed with depression according to International Classification of Diseases Tenth Revision (ICD10). Of these, approx. 4000 are also diagnosed with asthma, approx. 1000 with chronic kidney disease, approx. 3000 with diabetes and approx. 1700 with stroke.

Aims:

Using advanced computational methods, such as Machine Learning, we aim to stratify mental health patients based on associated comorbidities and identify biomarkers (genomic, biochemical, demographic, etc.) which can help in better diagnosis of those stratified groups.

Prospective candidate:

The project will be entirely computational. Thus, we are seeking a student having a strong interest in computational approaches evidenced by good programming skills (preferable in Linux, MATLAB, C/C++, Python or R) and knowledge in biomedical/biological sciences, computational biology and statistics. However, students from more biology oriented background but strong interest to learn bioinformatics and programming are also encouraged to apply. Appropriate training will be provided during the course of PhD study. For any informal enquiry and/or to discuss more about the project, please contact the lead supervisor or any member of the supervisory team. Contact details of the supervisory team are mentioned on the right hand side of this webpage.

Researcher will be based at C-TRIC (Altnagelvin Hospital site).

References:

1. World Health Organization. (2018). Depression. [online] Available at: http://www.who.int/mediacentre/factsheets/fs369/en/

2. Global Burden of Disease Study 2013 Collaborators. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (London, England), 386 (9995), 743-800.

3. Bunting, BP, Murphy, SD, O'Neill, SM & Ferry, FR. (2012). 'Lifetime prevalence of mental health disorders and delay in treatment following initial onset: evidence from the Northern Ireland Study of Health and Stress', Psychol Med, vol. 42, no. 8, pp.1727-39.

4. Smith, DJ, Court, H, McLean, G, Martin, D, Langan Martin, J, Guthrie, B, Gunn, J & Mercer SW. (2014). 'Depression and multimorbidity: a cross-sectional study of 1,751,841 patients in primary care', J Clin Psychiatry, vol. 75, no. 11, pp. 1202-8.


Essential criteria

  • To hold, or expect to achieve by 15 August, an Upper Second Class Honours (2:1) Degree or equivalent from a UK institution (or overseas award deemed to be equivalent via UK NARIC) in a related or cognate field.
  • Sound understanding of subject area as evidenced by a comprehensive research proposal

Desirable Criteria

If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview.

  • Completion of Masters at a level equivalent to commendation or distinction at Ulster
  • Experience using research methods or other approaches relevant to the subject domain
  • Work experience relevant to the proposed project
  • Publications - peer-reviewed
  • Publications record appropriate to career stage
  • Experience of presentation of research findings
  • A comprehensive and articulate personal statement
  • Use of personal initiative as evidenced by record of work above that normally expected at career stage.
  • Relevant professional qualification and/or a Degree in a Health or Health related area

Funding

    The University offers the following awards to support PhD study and applications are invited from UK, EU and overseas for the following levels of support:

    Vice Chancellors Research Studentship (VCRS)

    Full award (full-time PhD fees + DfE level of maintenance grant + RTSG for 3 years).

    This scholarship will cover full-time PhD tuition fees and provide the recipient with £15,000 maintenance grant per annum for three years (subject to satisfactory academic performance). This scholarship also comes with £900 per annum for three years as a research training support grant (RTSG) allocation to help support the PhD researcher.

    Vice-Chancellor’s Research Bursary (VCRB)

    Part award (full-time PhD fees + 50% DfE level of maintenance grant + RTSG for 3 years).

    This scholarship will cover full-time PhD tuition fees and provide the recipient with £7,500 maintenance grant per annum for three years (subject to satisfactory academic performance). This scholarship also comes with £900 per annum for three years as a research training support grant (RTSG) allocation to help support the PhD researcher.

    Vice-Chancellor’s Research Fees Bursary (VCRFB)

    Fees only award (PhD fees + RTSG for 3 years).

    This scholarship will cover full-time PhD tuition fees for three years (subject to satisfactory academic performance). This scholarship also comes with £900 per annum for three years as a research training support grant (RTSG) allocation to help support the PhD researcher.

    Department for the Economy (DFE)

    The scholarship will cover tuition fees at the Home rate and a maintenance allowance of £ 15,009 per annum for three years. EU applicants will only be eligible for the fee’s component of the studentship (no maintenance award is provided). For Non-EU nationals the candidate must be "settled" in the UK. This scholarship also comes with £900 per annum for three years as a research training support grant (RTSG) allocation to help support the PhD researcher.

    Due consideration should be given to financing your studies; for further information on cost of living etc. please refer to: www.ulster.ac.uk/doctoralcollege/postgraduate-research/fees-and-funding/financing-your-studies


Other information


The Doctoral College at Ulster University


Reviews

My experience has been great and the people that I have worked with have been amazing

Kieran O'Donnell - 3D printing of biological cells for tissue engineering applications

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Completing the MRes provided me with a lot of different skills, particularly in research methods and lab skills.

Michelle Clements Clements - MRes - Life and Health Sciences

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Throughout my PhD I’ve been provided with continuous support and guidance by my supervisors and the staff at the University.I’ve also received many opportunities to further enhance my professional development in the form of teaching experience and presenting my work at conferences which will aid in my pursuit of a career in academia or industry.

William Crowe


Key dates

Submission deadline
Friday 7 February 2020

Interview Date
9 to 20 March 2020


Applying

Apply Online  


Campus

Magee campus

Magee campus
A key player in the economy of the north west


Contact supervisor

Dr Priyank Shukla


Other supervisors

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