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Regenerative approaches have been used to successfully create patient-specific induced pluripotent stem cell (iPSC) models in collaboration with University of Galway, with CRISPR-Cas9 gene-editing employed to generate MTHFR 677 isogenic iPSC lines to investigate epigenomic differences, a crucial step in decoding the biological significance of this genetic variant in hypertension pharmacogenomics.
Lead Investigator
Professor Diane Lees-Murdock
Professor of Genomic Medicine
