Regenerative approach to nutrigenomics of hypertension

Regenerative approaches have been used to successfully create patient-specific induced pluripotent stem cell (iPSC) models in collaboration with University of Galway, with CRISPR-Cas9 gene-editing employed to generate MTHFR 677 isogenic iPSC lines to investigate epigenomic differences, a crucial step in decoding the biological significance of this genetic variant in hypertension pharmacogenomics.