Funded PhD Opportunity Chronic Wounds in the Community: A Smart Device Approach to Detecting the Early Onset of Infection.

This opportunity is now closed.

Subjects: Biomedical Sciences and Engineering

Summary

Background: Chronic wounds are widely regarded as a silent epidemic that affects a significant proportion of the populace and are typified by diabetic foot, venous leg or pressure ulcers. In most cases, the healing processes are stalled resulting in a wound that can persist for months if not years leaving the patient susceptible to further complications and life threatening events. The burden of treatment is expected to increase dramatically in the future with ever rising healthcare costs, an aging population and increases in diabetes and obesity (critical comorbidities). In the vast majority of cases, wound management is largely conducted within the community with the patient and/or healthcare professional relying on the recognition of subtle local indicators or non-specific general signs.

Vision, Aims and Focus:  The ultimate goal is to produce a new generation of intelligent wound dressing that can monitor the condition of the wound - reporting directly to the patient and/or healthcare practitioner to dramatically improve response time - facilitating healing and minimising the consequences of infection. The underpinning sensor design has undergone a successful first stage clinical study at Belfast City Hospital to confirm that the electroanalytical measurements are not unduly influenced by wound slough or dressing composition. The project proposed here will build on the technology base and focus on configuring the selectivity of the sensor towards the measurement of key inflammation markers within the wound environment.

The prime target is C-reactive protein (CRP) where high values reflect inflammation and/or tissue damage more precisely than other factors [1].  While CRP concentrations <8 mg/L are considered a normal clinical condition in wounds [2], higher values are routinely used to discriminate infection [3]. Such measurements could be invaluable for community based diagnosis and enable more timely recall and positive interventions.

Year 1. Validation of the CRP sensor for the smart bandage beyond the bench top is crucial. This will require the development of novel antibody immobilisation protocols and sensing methodologies and ex-vivo modeling to ensure ability to detect elevated CRP in complex biofluids.

Year 2. Sensor optimisation and validation of modified sensors against existing blood samples with known CRP concentrations from large well characterised nutrition studies. Investigate translation of methodology to other inflammatory markers (lysozyme etc).

Year 3.  Transfer technology to clinical setting and assess performance of validated CRP sensors in a clinical setting (Belfast City Hospital, Podiatry/Diabetes clinic).

Outcome and Alignment to 5&50 Strategy: The study would lay critical foundations for the development of a device that would cut across the 5&50 goals – dramatically improving the health of the patient, increasing efficiency of health care resources and enabling speedier returns to employment In the UK, some 650,000 patients suffer from some form of chronic wound with published estimates suggesting that the combined cost to the NHS for their treatment reaches approximately £3 bn pa.

References:

1.Pepys & Hirschfield. Clin. Investig. 2003,111,1805;

2.Kingsley & Jones. Wounds UK 2008,4,32–46;

3.Legendre et al. J. Vasc.Surg. 2008,48,688

Essential Criteria

  • Upper Second Class Honours (2:1) Degree or equivalent from a UK institution (or overseas award deemed to be equivalent via UK NARIC)
  • Sound understanding of subject area as evidenced by a comprehensive research proposal

Desirable Criteria

If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview.

  • First Class Honours (1st) Degree
  • Masters at 65%
  • Research project completion within taught Masters degree or MRES
  • Practice-based research experience and/or dissemination
  • Experience using research methods or other approaches relevant to the subject domain
  • Work experience relevant to the proposed project
  • Publications - peer-reviewed
  • Experience of presentation of research findings
  • A comprehensive and articulate personal statement
  • Relevant professional qualification and/or a Degree in a Health or Health related area

Funding

    DFE

    The scholarship will cover tuition fees at the Home rate and a maintenance allowance of £15,009 per annum for three years. EU applicants will only be eligible for the fees component of the studentship (no maintenance award is provided).  For Non EU nationals the candidate must be "settled" in the UK.

Other information

The Doctoral College at Ulster University

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Current PhD researchers and an alumnus shared their experiences, career development and the social impact of their work at the launch of the Doctoral College at Ulster University.

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Reviews


My experience has been great and the people that I have worked with have been amazing

Kieran O'Donnell - 3D printing of biological cells for tissue engineering applications

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Completing the MRes provided me with a lot of different skills, particularly in research methods and lab skills.

Michelle Clements Clements - MRes - Life and Health Sciences

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Throughout my PhD I’ve been provided with continuous support and guidance by my supervisors and the staff at the University.I’ve also received many opportunities to further enhance my professional development in the form of teaching experience and presenting my work at conferences which will aid in my pursuit of a career in academia or industry.

William Crowe


Key Dates

Submission Deadline
Monday 18 February 2019
Interview Date
Weeks commencing 11, 18, 25 March 2019

Campus

Coleraine campus

Coleraine campus
Our coastal and riverside campus focussing on science and health

Contact Supervisor

Dr Kirsty Pourshahidi

Other Supervisors

Apply online

Visit https://www.ulster.ac.uk/applyonline and quote reference number #343901 when applying for this PhD opportunity