Funded PhD Opportunity Isolation and characterization of phytochemicals with insulin-releasing or glucose lowering effects for the treatment of type-2 diabetes
Subject: Biomedical Sciences
Before the discovery of insulin in 1922, diets and plant-based treatments were the common approaches to diabetes therapy. In addition to metformin that was developed from a Galega officinalis, research evidence is being increasingly published to show that many plant derived bioactive compounds have the potential for development into drugs for treating type-2 diabetes. Previous studies in our laboratory have also provided research evidence for the potential of extracts of some plant species as candidates for development into antidiabetic agents.
Recently, we isolated a number of insulinotropic compounds from the extracts and these compounds exhibited potent in vitro insulin-releasing effects on BRIN-BD11 cells. They also improved glucose tolerance and enhanced insulin release in animals with obesity-diabetes on a short-term basis. The overall aim of this research is structural characterization and evaluation of biological activities of compounds recently isolated from extracts of traditional antidiabetic plant for potential development as novel type 2 diabetes drugs. It may also be possible to incorporate into the project other plant species with reputed antidiabetic properties depending on the interests of the applicant.
The proposed research will provide training in a wide range of techniques including: RP-HPLC, NMR, Ultrasound-assisted sequential extraction, Thin Layer Chromatography (TLC), Flash Chromatography, MALDI-TOF mass spectrometry; tissue culture; measurement of insulin secretion, signalling molecules (intracellular Ca2+ and other second messenger pathways); peptide iodination, cell morphology; ELISA; RIA; short studies in animal of obesity-diabetes. Established collaborations are in place for structural characterization and large scale purification of plant materials. This research will generate novel IP, high quality publications and potential exploitation through pharmaceutical development.
Applicants should note that Bench fees of £3500.00 per annum are required.
1.JMA Hannan, OO Ojo, L. Ali, B. Rokeya, J. Khaleque, m. Akhter, PR Flatt and YHA Abdel-Wahab (2015). Actions underlying antidiabetic effects of Ocimum sanctum leaf extracts in animal models of type 1 and type 2 diabetes. European Journal of Medicinal Plants, 5(1): 1-12.
2.V. Kasabri, P. R. Flatt and Y. H. A. Abdel-Wahab (2014). In vitro Modulation of Pancreatic Insulin Secretion and Extrapancreatic Insulin Action, Enzymatic Starch Digestion and Protein Glycation by Terminalia Chebula Extracts. European Journal of Medicinal Plants. 4(7): 771-782.
- Upper Second Class Honours (2:1) Degree from a UK institution (or overseas award deemed equivalent via UK NARIC)
- Sound understanding of subject area as evidenced by a comprehensive research proposal
If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview.
- First Class Honours (1st) Degree
- Masters at 65%
- Research project completion within taught Masters degree or MRES
- Practice-based research experience and/or dissemination
- Experience using research methods or other approaches relevant to the subject domain
- Work experience relevant to the proposed project
- Publications - peer-reviewed
- Experience of presentation of research findings
- A comprehensive and articulate personal statement
- Relevant professional qualification and/or a Degree in a Health or Health related area
Vice Chancellors Research Scholarships (VCRS)
The scholarships will cover tuition fees and a maintenance award of £14,777 per annum for three years (subject to satisfactory academic performance). Applications are invited from UK, European Union and overseas students.
The scholarship will cover tuition fees at the Home rate and a maintenance allowance of £ 14,777 per annum for three years. EU applicants will only be eligible for the fees component of the studentship (no maintenance award is provided). For Non EU nationals the candidate must be "settled" in the UK.
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- Submission Deadline
- Monday 18 February 2019
- Interview Date
- w/c 11, 18, 25 March 2019
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