Funded PhD Opportunity Low energy plasma radiotherapy – could this be a route to gentle and effective treatment of cancer or antibiotic resistant microbes?.
This opportunity is now closed.
Cold plasmas show great potential to kill cancer cells or highly antibiotic resistant microbes in wounds. Now we ask if we could create an ultra-low energy alternative to chemo-radiotherapy that would avoid the side effects of high energy radiotherapy. Cold plasmas in contact with liquids create complex chemical cocktails. We understand little of their chemical properties but their destructive effects on tumour cells or resistant microbes are remarkable. To prove our idea and turn it into a viable treatment technology will require a multidisciplinary effort involving a team with skills in plasmas, physics, chemistry, biology, microbiology and biomedical, electronic or mechanical engineering.
We are looking for keen students, from ANY discipline, to join our team with a PhD project individually tailored to their skills/interests. Example projects are:
(i) the interaction between plasmas and DNA/RNA or living cells; we have a unique experimental setup where we can directly expose molecules or living cells to reactive radicals with different doses. For the first time ever we hope to supply highly reactive electrons at very low energy and test their effect. These electrons could be critically important in understanding chemo-radiotherapy processes at the lowest energies.
(ii) design of systems that will bring plasma treated liquids rapidly into the body or onto a wound: a plasma can create highly effective plasma active liquids (PAL) for cancer of antibiotic resistant treatment. It is important that the time between PAL creation and interaction with biology is very short (< milliseconds). We have developed a system of creating PAL in flight using a stream of droplets for direct delivery to the tissue. The droplets are charged, so we are looking to use this and other factors to help steer the droplets. An ultimate objective is a method to deliver droplets along a tube deep into the body.
(iii) physics and/or chemistry of plasma-liquid interactions through experiment or simulation: it is difficult to measure the concentration of reactive radicals because they last only for a very short time. There are new simulation packages available that will help build a model of plasma and liquid chemistry and how it changes with time.
(iv) plasma-liquid synthesis of nanomaterials for bio-diagnostics-therapeutics: we have already demonstrated the ability with droplets to rapidly create nanomaterials such as gold nanoparticles and then deliver droplets with the nanoparticles directly to point of use. This could be useful in many applications and very valuable medically for biodiagnostics and therapy e.g. in cancer treatment. Apart from direct delivery, our nanoparticles are pristine i.e. they don’t have to be coated in protective layers and so may have much greater efficacy.
(v) design of new plasma electronics; before plasma systems can be fully integrated into medical applications, we need RF design (at LF – VHF) to miniaturise our devices and to improve the feedback control.
(vi) design of new plasma-based microfluidic devices. Prior knowledge of plasmas NOT required. For some projects, familiarity with aspects of plasmas would beneficial but not essential.
- Upper Second Class Honours (2:1) Degree from a UK institution (or overseas award deemed equivalent via UK NARIC)
Vice Chancellors Research Scholarships (VCRS)
The scholarships will cover tuition fees and a maintenance award of £14,777 per annum for three years (subject to satisfactory academic performance). Applications are invited from UK, European Union and overseas students.
The scholarship will cover tuition fees at the Home rate and a maintenance allowance of £ 14,777 per annum for three years. EU applicants will only be eligible for the fees component of the studentship (no maintenance award is provided). For Non EU nationals the candidate must be "settled" in the UK.
The Doctoral College at Ulster University
Launch of the Doctoral College
Current PhD researchers and an alumnus shared their experiences, career development and the social impact of their work at the launch of the Doctoral College at Ulster University.Watch Video