
New therapeutics for ‘diabesity’
UU
spin-out company, Diabetica Limited, is developing new
therapeutics with which to tackle ‘diabesity’, the diabetes and
obesity epidemic which represents one of the world’s major
healthcare and socioeconomic challenges.
Diabetica was established in 2004 to exploit research
discoveries at UU’s internationally renowned Diabetes Research
Group. The company has established a rich patent-portfolio
covering a number of important therapeutic and diagnostic
technologies for diabetes and obesity.
Particular focus has been directed to Diabetica’s novel GIP
(glucose-dependent insulinotropic polypeptide)
platform-technology. The company has a growing patent-estate
covering development of therapeutic products based on naturally
occurring GIP gut peptide, exerting a number of effects that
help the body maintain appropriate blood sugar levels.
Diabetica announced last year an exclusive out-licence to Amylin
Pharmaceuticals Inc, a world leader in diabetes therapeutics, to
develop insulin-stimulating GIP agonist drugs, a deal that in
time could total US$41million, as well as royalties on future
sales.
Dr
Neville McClenaghan, COO of Diabetica, said: “Diabetica has also
established a further agreement with the diagnostics-arm of a
global pharmaceutical company, to determine commercial viability
of a novel biomarker for pre-diabetes/diabetes, discovered by UU
scientists.
“Additionally we are developing proprietary insulin-sensitizing
GIP antagonists, a new class of drug which our data indicates
may provide effective non-invasive therapeutic tools with which
to manage weight gain, clinical obesity and associated
diabetes.”
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